Protection mechanism of human cell upon radioadaptive response and the interferon antimutagenic action possess
نویسندگان
چکیده
منابع مشابه
Radioadaptive Response in Human Lymphocyte Cells
The adaptive response (AR) is a phenomenon by which cells exposure to sublethal doses of DNA-damaging agents (non-mutagenic dose of chemical or radiation), known as conditioning treatment (CT), leads to increased resistance to a subsequent exposure to a higher dose of the same or other agents, known as challenge treatment (CR). The adaptive response (AR) induced by radiation in human lymphocyte...
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Background : There are growing evidences for chromosomal radioadaptive response in human lymphocytes . Highly variable inter- and intra-individual responses have been reported. Some individuals are non-responders and even in some donors the frequency of chromatid aberrations induced by a challenge dose increases by pre-exposure to an adapting dose. It has been proposed that the lack of radioada...
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The double-stranded RNA (dsRNA)-dependent protein kinase which catalyzes the phosphorylation of ribosome-associated protein Pl and the a subunit of eukaryotic protein synthesis initiation factor 2 (eIF-2) was purified and characterized from mouse fibroblast L929 cells treated with either natural or recombinant interferon and from untreated cells. The dsRNA-dependent Pl/eIF-2a kinase was purifie...
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Interferon-γ (IFN-γ) is a pleiotropic cytokine with antiproliferative and immunomodulatory activities that are crucial for the regulation of immune responses. We examined a group of military pilots. The examinees were divided into 3 subgroups: ground personnel (9 persons, control group), 17 pilots with <1000 h flight time, and 12 pilots with >1000 h flight time. No differences in IFN-α serum co...
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In this work, the mechanism of cell bleb formation upon the addition of cryoprotectants (CPAs) was investigated, and the role of cell blebs in protecting cells was determined. The results show that after adding CPAs, the hyperosmotic stress results in the breakage of the cortical cytoskeleton and the detachment of the cell membrane from the cortical cytoskeleton, causing the formation of cell b...
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ژورنال
عنوان ژورنال: Radioprotection
سال: 2008
ISSN: 0033-8451,1769-700X
DOI: 10.1051/radiopro:2008725